|
|
|
|
|
| Marcaillou-le Baut, Claire; Masselin, Pierre; Bohec, Madeleine; Truquet, Philippe; Amzil, Zouher; Pouchus, Francois; Le Boterff, Jean; Verbist, Jean-françois; Vernoux, Jean-paul; Marais, Chantal; Simon, Jean-françois; Nizard, Gabrielle; Mercier, Géraldine; Choumiloff, Roxelan; Baron, Bruno. |
| Cette étude est le résultat d'un travail de trois équipes: elle porte sur la comparaison du test souris avec différents bioessais déjà pratiqués en routine dans les laboratoires participants. Ces bioessais sont : - un test sur micro crustacé dont la méthodologie est normalisée et qui est très utilisé en écotoxicologie aquatique ; - un test de cytotoxicité à court terme qui a été mis au point pour cette étude. |
| Tipo: Text |
|
| Ano: 1992 |
URL: http://archimer.ifremer.fr/doc/00139/25035/23144.pdf |
| |
|
|
| Arnich, Nathalie; Abadie, Eric; Delcourt, Nicolas; Fessard, Valérie; Fremy, Jean-marc; Hort, Vincent; Lagrange, Emmeline; Maignien, Thomas; Molgó, Jordi; Peyrat, Marie-bénédicte; Vernoux, Jean-paul; Mattei, César. |
| Pinnatoxins (PnTXs) are a group of emerging marine biotoxins produced by the benthic dinoflagellate Vulcanodinium rugosum, currently not regulated in Europe or in any other country in the world. In France, PnTXs were detected for the first time in 2011, in mussels from the Ingril lagoon (South of France, Mediterranean coast). Since then, analyses carried out in mussels from this lagoon have shown high concentrations of PnTXs for several months each year. PnTXs have also been detected, to a lesser extent, in mussels from other Mediterranean lagoons and on the Atlantic and Corsican coasts. In the French data, the main analog is PnTX G (low levels of PnTX A are also present in some samples). No cases of PnTXs poisoning in humans have been reported so far in... |
| Tipo: Text |
Palavras-chave: Pinnatoxins; Shellfish; Emerging marine biotoxins; Risk assessment. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00619/73105/72236.pdf |
| |
|
|
| Delcourt, Nicolas; Lagrange, Emmeline; Abadie, Eric; Fessard, Valérie; Frémy, Jean-marc; Vernoux, Jean-paul; Peyrat, Marie-bénédicte; Maignien, Thomas; Arnich, Nathalie; Molgó, Jordi; Mattei, César. |
| Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been reported to date although acute toxicity was induced by PnTxs in rodents. LD50 values have been estimated for the different PnTXs through the oral route. At sublethal doses, all symptoms are reversible, and no neurological sequelae are visible. These symptoms are consistent with impairment of central and peripheral cholinergic network functions. In fact, PnTXs are high-affinity competitive antagonists of nicotinic acetylcholine receptors (nAChRs).... |
| Tipo: Text |
Palavras-chave: Pinnatoxins; Cyclic imines; Vulcanodinium rugosum; Nicotinic acetylcholine receptors; Acute neurotoxicity; Human intoxication; Myasthenia gravis. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00507/61883/65958.pdf |
| |
|
|
| Gueguen, Marielle; Amiard, Jean-claude; Arnich, Nathalie; Badot, Pierre-marie; Claisse, Didier; Guerin, Thierry; Vernoux, Jean-paul. |
| Shellfish farming is a common industry along European coasts. According to the 2005–2006 data from the French National Shellfish Farming Committee (CNC – Comité National de la Conchyliculture 2010; see Table 1 for a list of acronyms and abbreviations used in this chapter), Spain is the largest shellfish producer in Europe (∼270,000 t) and France ranks second, producing 200,000 t of shellfish annually. France is the leading European oyster producer, with an annual output of 130,000 t of Crassostrea gigas, and ranks fourth in the world after China, Japan, and Korea. The top three European mussel (Mytilus edulis and Mytilus galloprovincialis) producers are Spain (260,000 t), Denmark (80,000 t), and France (65,000 t). For other shellfish, the French annual... |
| Tipo: Text |
|
| Ano: 2011 |
URL: http://archimer.ifremer.fr/doc/00039/14995/12622.pdf |
| |
|
|
|
